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为了动态观察华支睾吸虫病的胆道超微结构变化过程，以实验感染华支睾吸虫的豚鼠为模型，对其胆道上皮细胞进行了２２周的观察，发现主要改变为：胆道上皮细胞微绒毛的肿胀，融合或消失；胆管上皮细胞向管腔面异常隆起；胞质减少，胞浆黏液颗粒大量增加；细胞间隙增宽，胶原原纤维向内生长；核形态不规则；线粒体数量增加，体积增大，肿胀，基质减少或空泡化，或浓缩为髓样体；高尔基复合体活跃；内质网数量增加，内质网池扩张；溶酶体增加；基膜弯曲，基膜下胶原原纤维增生及嗜酸粒细胞浸润，其病变程度随时间延长呈加重趋势，反映了胆管上皮细胞受破坏及功能反应性增强交叉进行的病理过程。
In order to dynamically observe the ultrastructural changes of biliary tract of Clonorchis sinensis, the guinea pigs experimentally infected with Clonorchis sinensis were taken as the model and their biliary epithelial cells were observed for 22 weeks. The main changes were found as follows: biliary epithelial microvilli Swelling, fusion or disappearance of bile duct epithelial cells; abnormal elevation of bile duct epithelium to luminal surface; decrease of cytoplasm; increase of cytoplasm mucus particles; broadening of intercellular space and in-growth of collagen fibrils; irregular nuclear morphology; increasing number of mitochondria, Enlarged, swollen, stromal reduced or vacuolized, or concentrated to myeloid; active in the Golgi complex; increased in the number of endoplasmic reticulum, expansion of the endoplasmic reticulum cell; increased lysosomes; bending of the basement membrane, collagen in the basement membrane Fibrosis and eosinophil infiltration, the extent of the lesion showed an aggravating trend with time, reflecting the destruction of bile duct epithelial cells and increased functional response of the cross-pathological process.