围生窒息所致的缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)是引起新生儿死亡和神经系统后遗症的主要原因。早期诊断HIE对于降低新生儿病死率和减轻神经系统后遗症具有重大的意义。但是迄今为止,尚无可靠、简便的方法早期预测窒息新生儿是否会发生HIE。S100B蛋白是神 Hypoxic-ischemic encephalopathy (HIE) caused by perinatal asphyxia is the main cause of neonatal death and neurological sequelae. Early diagnosis of HIE is of great importance in reducing neonatal mortality and reducing neurological sequelae. However, so far, there is no reliable and easy way to predict whether HIE will occur in neonates with asphyxia at an early stage. S100B protein is God