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采用ＥＬＩＳＡ检测３９名不同类型牙周病患者的血清及其１５６颗患牙的龈沟液（ＧＣＦ）中抗牙龈叶琳菌（Ｐｇ）抗体（ＩｇＧ）水平，并用间接免疫荧光法检测龈下菌斑中的Ｐｇ，观察Ｐｇ检出量、血清（Ｓｒ）和ＧＣＦ抗体水平、二者抗体水平比值（ＧＣＦ／Ｓｒ比值）以及与临床指数间的关系。结果显示，Ｐｇ检出量与疾病类型、临床指数呈正相关，与ＧＣＦ抗Ｐｇ抗体及ＧＣＦ／Ｓｒ比值呈负相关。初步证实龈下菌斑中细菌量增多，会使ＧＣＦ中相应抗体水平下降，从而使ＧＣＦ／Ｓｒ比值降低。ＧＣＦ抗Ｐｇ抗体水平、ＧＣＦ／Ｓｒ比值及龈下菌斑中Ｐｇ检出量结合起来，有可能成为牙周病活动期的诊断指标。
The levels of anti-Gg antibody against gingival crevicular fluid (GCG) in 39 different types of periodontal disease patients and their GCFs were measured by ELISA. The levels of IgG in subgingival bacteria Plaque in the Pg, observed Pg detection, serum (Sr) and GCF antibody levels, the ratio of the two antibody levels (GCF / Sr ratio) and the relationship between the clinical index. The results showed that the detection of Pg was positively correlated with the type of disease and clinical index, and negatively correlated with the anti-Pg antibody and GCF / Sr ratio of GCF. Preliminary evidence of increased subgingival plaque bacteria, GCF will reduce the corresponding antibody levels, so that GCF / Sr ratio decreased. GCF anti-Pg antibody levels, GCF / Sr ratio and subgingival plaque detection of Pg combined, may become an indicator of periodontal disease activity.