干扰素是目前治疗慢性丙型肝炎有效的抗病毒药物,约50％患者治疗有应答,20％呈持续应答。影响干扰素治疗应答的因素尚不清楚。近有两种新方法,即分枝DNA信号扩增法(b DNA,用于血清HCV RNA定量分析)和逆向杂交法(LIPA,用于HCV基因分型)能提供规范、可靠的HCV RNA定量和HCV基因型别的分析。 Interferon is currently an effective antiviral agent for the treatment of chronic hepatitis C. About 50% of patients respond to treatment, and 20% have a sustained response. The factors that influence the response to interferon therapy are unclear. Nearly two new approaches, branching DNA signal amplification (b DNA for serum HCV RNA quantitation) and reverse hybridization (LIPA for HCV genotyping), provide a normative and reliable quantification of HCV RNA And HCV genotype analysis.