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一项美国研究显示，口服甲基纳曲酮（ｍｅｔｈｙｌｎａｌｔｒｅｘｏｎｅ）可有效治疗长期使用美沙酮治疗者的便秘。 １２例病人在第１大口服安慰剂，第２天口服本品单一剂量 ０．３、 １或 ３ｍｇ／ｋｇ。结果，第 １大未见肠蠕动；本品０．３ｍｇ／ｋｇ组４例病人在第２和３天
A US study shows that oral methylnaltrexone is effective in treating constipation in long-term methadone-treated patients. 12 patients in the first large oral placebo, oral administration of a single dose of 0.3, 1 or 3mg / kg. Results, the first large intestinal peristalsis; 0.3mg / kg group of 4 patients in the first 2 and 3 days