癌症基因治疗中的一个基本策略是局部控制肿瘤生长,体内基因转染可以使目的基因集中在靶组织内,用这一方法可以转染一些编码酶的基因,当它们在肿瘤细胞内或周围组织中表达时,一些全身应用的非抗肿瘤的低毒性药物在这一局部被代谢成抗肿瘤的具有较高毒性的产物,使其在肿瘤局部发挥作用,并避免了全身毒性。胞嘧啶脱氨酶(CD)是这类基因中的一种。为观察体内转染 A basic strategy in cancer gene therapy is to locally control tumor growth. In vivo gene transfection allows the target gene to be concentrated in the target tissue. In this way, some genes encoding enzymes can be transfected when they are in or around tumor cells. In expression, some non-anti-tumor, low-toxicity drugs that are systemically applied are metabolized to anti-tumor, highly toxic products at this site, allowing them to act locally in the tumor and avoid systemic toxicity. Cytosine deaminase (CD) is one of these genes. To observe transfection in vivo