目的寻找术后反应轻微、长期疗效可靠的根管充填材料。方法将需要根管治疗的患牙随机分成3组,分别采用氧化锌糊剂加牙胶尖、AH plus糊剂加牙胶尖、Cortisomol糊剂加牙胶尖行一次性根管治疗,分析其24～72h内急性反应和1 a后远期效果。结果 3种材料的急性反应存在统计学差异,Cortisomol组反应最轻,AH plus次之,氧化锌较重,而远期效果并无统计学差异。结论 Cortisomol是较为合适的一次性根充材料。 Objective To find the root canal filling material with mild postoperative reaction and long-term curative effect. Methods The teeth requiring root canal therapy were randomly divided into 3 groups: zinc paste plus gingiva tip, AH plus paste plus gingivitis tip, Cortisomol paste plus gingivitis tip with one-time root canal treatment, 24 ~ 72h acute reaction and 1 a after the long-term effect. Results There was a significant difference in the acute reactions between the three materials. Cortisomol group had the least reaction, followed by AH plus and zinc oxide. However, the long-term effects were not statistically different. Conclusion Cortisomol is a more suitable one-time root-filling material.