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目的 :观察清肝利胆浸膏对急性肝损伤的保护作用和利胆、退黄作用。方法 :用CCL4 和D -GaL致小鼠急性肝损伤 ,观察血清ALT和AST ;用麻醉大鼠胆管收集胆汁 ,测定胆汁中胆固醇和总胆红素的含量 ;用异硫氰酸 -1 -萘酯造成黄疸模型 ,测定血清中ALT和AST、总胆红素。结果 :清肝利胆浸膏能显著降低CCL4 致小鼠ALT和AST升高 ,对D -GaL致小鼠ALT和AST升高亦有明显降低 ,对大鼠胆汁分泌有增加 ,对胆汁成份胆固醇、总胆红素升高有明显的降低。结论 :清肝利胆浸膏具有一定的保肝降酶、利胆和退黄作用
Objective : To observe the protective effect of Qinggan Lidan extract on acute liver injury and the effect of gallbladder and jaundice. METHODS: Acute hepatic injury was induced in mice with CCL4 and D-GaL. Serum ALT and AST were observed. Bile was collected from bile ducts of anesthetized rats to determine cholesterol and total bilirubin levels in bile; isothiocyanate-1-naphthalene was used. Ester caused jaundice model, serum ALT and AST, total bilirubin. Results: Qinggan Lidan extract can significantly reduce the elevation of ALT and AST in mice induced by CCL4. The increase of ALT and AST in mice induced by D-GaL is also significantly reduced. The secretion of bile is increased in rats, and the cholesterol in cholesterol is increased. Elevated total bilirubin was significantly reduced. Conclusion : Qinggan Lidan extract has a certain role in protecting the liver and reducing enzymes, gallbladder and jaundice