真核生物蛋白合成始动因子 ４Ｅ（ ｐｒｏｔｅｉｎ ｅｕｋａｒｙｏｔｉｃｉｎｉｔｉａｔｉｏｎｆａｃｔｏｒ４Ｅ，ｅＩＦ４Ｅ）在蛋白合成起始阶段起重要的调控作用。近几年来，体内外研究发现ｅＩＦ４Ｅ过度表达与恶性肿瘤发生发展有关，１９９６年始国外文献陆续报道，在头颈 Eukaryotic protein synthesis activator 4E (eIF4E) plays an important regulatory role in the initial stage of protein synthesis. In recent years, in vitro and in vivo studies found that eIF4E overexpression and the occurrence of malignant tumor related to foreign literature began in 1996 reported in the head and neck