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目的:评价肿瘤坏死因子-α基因G308A多态性位点对于结直肠癌患病风险的影响。方法:以“TNF-α-308、pol-ymorphism和colorectal cancer”作为检索词,检索2000-01-01-2011-09-01PubMed和Embase数据库中所有相关文献,提取其中数据进行统计分析,以比值比(OR)和95%可信区间(95%CI)评价该位点与结直肠癌易感性的关系。结果:最终筛选出9项关于该位点的研究,其中共包含了1 708例结直肠癌病例和1 754名对照。结果显示,A等位基因和G等位基因对于结直肠癌的患病风险差异无统计学意义,OR=1.89,95%CI为0.94～3.78;各种基因模式的对比也无阳性结果,GA对比GG,OR=1.16,95%CI为0.84～1.59,AA/GA对比GG,OR=1.26,95%CI为0.90～1.77,AA对比GA/GG,OR=1.75,95%CI为0.94～3.23。人种与对照来源进行的亚组分析中,也未发现有阳性结果。结论:肿瘤坏死因子-α基因G308A多态性可能对结直肠癌易感性无影响。建议今后应纳入更多的研究证据来明确该多态性位点与结直肠癌易感性的关系。
Objective: To evaluate the effect of G308A polymorphism of tumor necrosis factor-α gene on the risk of colorectal cancer. METHODS: All the relevant articles in the PubMed and Embase databases of 2000-01-01-2011-09-01 were searched with “TNF-α-308, pol-ymorphism and colorectal cancer”, and the data were extracted for statistical analysis. The odds ratio (OR) and 95% confidence interval (95% CI) were used to evaluate the relationship between this site and colorectal cancer susceptibility. RESULTS: Nine studies were screened for this site, which included a total of 1 708 cases of colorectal cancer and 1 754 controls. The results showed that there was no significant difference in the risk of colorectal cancer between A allele and G allele (OR = 1.89, 95% CI 0.94-3.78). There was also no positive result in the comparison of various gene patterns. GA OR = 1.16, OR = 1.16, 95% CI 0.84-1.59, AA / GA vs GG, OR = 1.26, 95% CI 0.90-1.77, AA vs GA / GG, OR = 1.75, 95% CI 0.94-3.23 . No positive results were found in the subgroup analysis of race and control sources. Conclusion: G308A polymorphism of tumor necrosis factor-α gene may have no effect on susceptibility to colorectal cancer. It is suggested that more research evidence should be included in the future to clarify the relationship between the polymorphic site and susceptibility to colorectal cancer.