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目的：探讨Ｅ－钙粘附素（Ｅ－ＣＤ）表达与胃癌发生发展及预后的关系。方法：采用ＳＰ免疫组化染色技术，检测２０例正常胃粘膜上皮，４３例异型增生和１０１例胃癌组织Ｅ－ＣＤ的表达情况。结果：正常胃粘膜和异型增生组织Ｅ－ＣＤ呈强阳性表达，８８．１％（８９／１０１）胃癌Ｅ－ＣＤ表达减弱，Ｅ－ＣＤ表达与胃癌分化差、浸润型生长显著相关（Ｐ＜０．０５），Ｅ－ＣＤ表达正常的胃癌病人术后３、５年生存率显著高于减弱者（Ｐ均＜０．０５）。结论：Ｅ－ＣＤ减弱表达与胃癌细胞分化差、浸润型生长及预后较差密切相关。
Objective: To investigate the relationship between the expression of E-cadherin (E-CD) and the occurrence, development and prognosis of gastric cancer. Methods: SP immunohistochemical staining technique was used to detect the expression of E-CD in 20 cases of normal gastric epithelium, 43 cases of dysplasia and 101 cases of gastric cancer. Results: The positive expression of E-CD in normal gastric mucosa and dysplasia tissues was strong, while the expression of E-CD in 88.1% (89/101) gastric cancers was decreased. The expression of E-CD was significantly correlated with poorly differentiated gastric cancer and invasive growth (P < 0.05). The 3-year and 5-year survival rates of gastric cancer patients with normal E-CD expression were significantly higher than those of weakened patients (all P <0.05). Conclusion: The decreased expression of E-CD is closely related to poor differentiation of gastric cancer cells, infiltrative growth and poor prognosis.