目的 :为了探讨超微量14 C 尿素呼气试验 (14 C UBT)对幽门螺杆菌感染的诊断价值及其影响因素。方法 :采用超微量 (2 8kBq) 14 C UBT检测了 139例患者 ,和 37例经三联治疗的HP感染者 ,并观察了抑酸药物对14 C UBT结果的影响。结果 :①14 C UBT与胃粘膜内Hp细菌学检测比较其特异性为 10 0 % ,敏感性为97.7% ,诊断符合率为98.6 %。②轻、中、重度HP感染组14 C UBT计数分别为 46 6 .5± 2 0 4.2dpm/mmolCO2 ,912 .8± 2 39.2dpm/mmolCO2 和 185 4.9± 473.6dpm/mmolCO2 ,各组间有显著差异 (P <0 .0 1)。③HP已根除者和未根除者14 C UBT计数分别为 47.1± 2 0 .1dpm/mmolCO2 和 72 5 .4± 35 7.0dpm/mmolCO2 ,二者有非常显著的差异 (P <0 .0 1)。④Hp感染者在使用抗酸药物过程中和停药 1月后的14 C UBT计数分别为 15 7.1± 137.3dpm/mmolCO2 和 815 .0± 2 6 0 .7dpm/mmolCO2 ,两者之间有显著差异 (P <0 .0 1)。结论 :①超微量14 C UBT方法诊断HP感染具有很高的特异性、敏感性。②14 C UBT的结果与Hp感染程度有密切关系。③14 C UBT可准确的判断HP是否根除。④抗酸药可明显影响14 C UBT的结果 Objective: To investigate the diagnostic value of Helicobacter pylori infection and its influencing factors in 14 C UBT (14 C urea breath test). METHODS: A total of 139 patients and 37 HP-infected patients treated with triple therapy were tested with ultra-trace (28kBq) 14 C UBT and the effect of acid-suppressing drugs on 14 C UBT results was observed. Results: ① The specificity of 14 C UBT and gastric mucosal Hp was 100%, the sensitivity was 97.7%, and the diagnostic coincidence rate was 98.6%. ② The counts of 14 C UBT in mild, moderate and severe HP infection group were 46.6 ± 2.5 4.2 dpm / mmolCO2, 912.8 ± 2 39.2 dpm / mmolCO2 and 185 4.9 ± 473.6 dpm / mmolCO2, respectively Difference (P <0. 01). ③ 14 C UBT counts of 47.1 ± 20.1 dpm / mmolCO 2 and 72 5 .4 ± 35 7.0 dpm / mmolCO 2, respectively, in patients with and without eradication of HP (P <0.01). ④ The 14 C UBT counts of patients with Hp infection during antacid treatment and after 1 month of withdrawal were 15 7.1 ± 137.3 dpm / mmolCO 2 and 815.0 ± 26.07 dpm / mmolCO 2, respectively, with significant differences between the two (P <0. 01). Conclusion: ① ultra-trace 14 C UBT diagnosis of HP infection has a high specificity and sensitivity. ② 14 C UBT results and Hp infection are closely related. ③ 14 C UBT can accurately determine whether HP eradicate. ④ Antacid drugs can significantly affect the 14 C UBT results