自1899年阿斯匹林在商业上推广后,很快注意到它的特异质反应,且患者多具有明确的症状。在20年或30年的时间内发展成间歇性流涕,以后持续加重常导致鼻息肉复发。数年内可形成哮喘,继之在30年中对阿斯匹林具有敏感性。这种情况在妇女和儿童中较为常见,且多无对其他外源性过敏元敏感的证据。类似的反应可由其他镇痛剂:包括消炎痛、乙比普鲁芬 Since its commercial introduction in 1899, aspirin quickly noticed its idiosyncratic response and many patients had definite symptoms. In 20 or 30 years of development into intermittent runny nose, continued to increase often lead to recurrence of nasal polyps. Asthma develops within a few years, followed by aspirin sensitivity for 30 years. This condition is more common in women and children and there is not much evidence of sensitivity to other exogenous allergens. A similar response may be caused by other analgesics: indomethacin, betaiprufen