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50KDa T11(CD2)表面糖蛋白是T淋巴细胞与绵羊细胞结合的受体,抗人类T11分子特定表位(T11_1)的单抗能阻断T细胞和羊红细胞的花环形成。CD2分子在T细胞活化过程中也起重要作用。本文作者构建了含人和小鼠编码CD2分子基因的DNA克隆。人和小鼠T11基因的限制性内切酶和
The 50 kDa T11 (CD2) surface glycoprotein is a T-lymphocyte receptor that binds to sheep cells. Monoclonal antibodies against T11 specific epitopes (T11_1) block the formation of T-cells and sheep erythrocytes. CD2 molecules also play an important role in T cell activation. The authors constructed DNA clones containing human and mouse CD2-encoding genes. Human and mouse T11 gene restriction endonucleases and