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目的观察失血性休克复苏大鼠肺组织中的NO、NOS的变化以及复方丹参注射液的影响,探讨失血性休克复苏大鼠肺损伤的机制及丹参的治疗机制。方法健康SD大鼠30只,随机均分成正常对照组(NC组)、失血性休克复苏组(HS组)和丹参治疗组(SM组)。实验结束时,取全肺测定肺系数,取血和肺组织测定一氧化氮(NO)含量和一氧化氮合酶(NOS)的活性,并对肺组织作光镜病理学检查。结果与HS组相比较,SM组血清和肺组织中的NO含量、NOS活性均显著升高;肺系数降低;肺组织病变明显减轻。结论大鼠失血性休克复苏后,NO的大量释放参与肺损伤过程,丹参对这种肺损伤有良好的保护作用。
Objective To observe the changes of NO and NOS in lung tissues of rats with hemorrhagic shock and resuscitation and the effects of compound Danshen injection. To explore the mechanism of lung injury and the mechanism of Salvia miltiorrhiza in rats with hemorrhagic shock resuscitation. Methods 30 healthy SD rats were randomly divided into normal control group (NC group), hemorrhagic shock resuscitation group (HS group) and Salvia miltiorrhiza treatment group (SM group). At the end of the experiment, the whole lung was used to determine the lung coefficient. Blood and lung tissues were collected to determine the content of nitric oxide (NO) and nitric oxide synthase (NOS), and light microscopy was performed on lung tissue. Results Compared with the HS group, serum NO and NOS activity in the serum and lung tissue of the SM group were significantly increased, lung coefficient was decreased, and lung tissue lesions were significantly reduced. Conclusion After resuscitation from hemorrhagic shock in rats, the release of NO was involved in the process of lung injury. Salvia miltiorrhiza has a good protective effect against this lung injury.