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目的调查医院内尿路感染病原菌的现状及体外耐药性,为临床提供科学诊断和治疗依据。方法对2006年7月-2008年6月门诊及住院患者尿液培养中分离出的168株病原菌进行鉴定和体外药物敏感试验。结果泌尿系感染以大肠埃希菌为主,占40.40%;肠杆菌科及革兰阳性球菌对抗菌药物耐药率均较严重,其中亚胺培南对革兰阴性杆菌作用最强,耐药率为0~10.00%;氨曲南、妥布霉素、阿米卡星、氨苄西林/舒巴坦也有较好的抗菌活性,其耐药率分别为0~70.00%、10.00%~30.88%、10.00%~57.14%3、7.50%~64.71%;革兰阳性球菌对青霉素普遍耐药,其耐药率为57.69%~100.00%,万古霉素的耐药率为0。结论泌尿系感染最主要的病原菌是大肠埃希菌,耐药呈上升趋势,合理使用抗菌药物,进一步重视病原菌的培养和药敏,是预防医院感染的重要措施。
Objective To investigate the status and drug resistance of urinary tract infection pathogens in hospitals and provide scientific basis for diagnosis and treatment. Methods 168 strains of pathogens isolated from the urine of outpatients and inpatients from July 2006 to June 2008 were identified and tested in vitro. Results The majority of urinary tract infections were Escherichia coli, accounting for 40.40%. Enterobacteriaceae and Gram-positive cocci were more resistant to antibiotics, of which, imipenem had the strongest effect on gram-negative bacilli and resistance Aztreonam, tobramycin, amikacin, ampicillin / sulbactam also have good antibacterial activity, the resistance rates were 0 ~ 70.00%, 10.00% ~ 30.88% , 10.00% -57.14% 3,7.50% -64.71%. Gram-positive cocci were generally resistant to penicillin. The resistance rate was 57.69% -100.00%, and vancomycin resistance rate was 0. Conclusions The most important pathogen of urinary tract infection is Escherichia coli, and its resistance is on the rise. It is an important measure to prevent nosocomial infections by using antibacterials reasonably and paying more attention to the culture and drug sensitivity of pathogenic bacteria.