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目的观察芪天滴丸对大鼠实验性血栓形成及血液流变学的影响。方法大鼠口服灌胃给药芪天滴丸60、120、240mg.kg-1,每日1次,持续5 d,末次给药后1 h观察芪天滴丸对大鼠实验性血栓形成时间、血小板聚集率及高黏血症大鼠全血黏度及血沉和红细胞压积的影响。结果芪天滴丸低、中、高剂量组能剂量依赖性延长动脉血栓形成时间,抑制血小板聚集,抑制高黏血症大鼠全血黏度及血沉的升高。结论芪天滴丸具有明显抗血栓形成和改善血液流变学作用。
Objective To observe the effect of Qitian Diwan on experimental thrombosis and hemorheology in rats. Methods The rats were orally administered with Qidian dropping pills 60,120,240mg.kg-1 once daily for 5 days. The experimental thrombosis time was observed 1 h after the last administration , Platelet aggregation rate and hyperviscosity in whole blood viscosity and erythrocyte sedimentation rate and hematocrit of rats. Results Qidian dropping pills in low, medium and high dose groups could prolong the time of arterial thrombosis, inhibit platelet aggregation and inhibit whole blood viscosity and erythrocyte sedimentation rate in hyperviscosity rats. Conclusion Qitian dripping pills have obvious anti-thrombosis and improve the role of hemorheology.