目的　评价单次注射喷昔洛韦在健康志愿者中的安全性和耐受性。方法　选择27名20~40岁健康志愿者,随机分配至4个剂量组,观察志愿者临床体征及各种生化指标。结果　在单次注射125,250,375和500 mg喷昔洛韦时,用药后24,72 h受试者的体征及实验室检查结果与给药前比较没有显著性差异。结论　受试者对喷昔洛韦具有很好的耐受性,推荐临床剂量1次 125 ~ 500 mg 可以接受。 Objective To evaluate the safety and tolerability of single injection of penciclovir in healthy volunteers. Methods Twenty-seven healthy volunteers aged 20-40 years were randomly assigned to four dose groups. The clinical signs and biochemical indexes of volunteers were observed. Results In single injection of penciclovir at 125, 250, 375 and 500 mg, signs and laboratory findings at 24 and 72 h after treatment were not significantly different from those before administration. Conclusions Subjects have a good tolerance to penciclovir. A clinical dose of 125 to 500 mg is recommended.