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目的通过检测造影剂相关性肾病患者尿液中β2微球蛋白(β2-MG)、N-乙酰-β-D-氨基葡萄糖苷酶(NAG)及肾损伤分子1(KIM-1)的水平,了解β2-MG、NAG及KIM-1在造影剂相关性肾病患者中的改变及其与肾功能之间的关系。方法收入49例造影剂相关性肾病患者,同时收入52例健康志愿者,以ELISA法分别检测其尿液中的β2-MG、NAG及KIM-1水平,分析其与患者肾功能之间的关系。结果造影剂相关性肾病患者尿液中β2-MG、NAG、KIM-1分别为(594.62±87.93)mg/L、(24.52±4.64)U/L、(4.68±0.83)ng/mL,均高于健康对照组[β2-MG(108.16±10.55)mg/L,NAG(8.74±1.75)U/L,KIM-1(0.28±0.10)ng/mL],差异有统计学意义(P均<0.05);患者组的肌酐清除率Ccr为(25.09±7.50)ml/min,低于健康对照组的(83.75±33.84)ml/min,差异亦有统计学意义(P<0.05)。结论造影剂相关性肾病患者尿液中β2-MG、NAG及KIM-1水平较健康对照组明显升高,反映了肾小管的损伤情况,可作为造影剂相关性肾病患者肾功能的检测指标。
Objective To detect the levels of β2-microglobulin, N-acetyl-β-D-glucosaminidase (NAG) and renal injury molecule 1 (KIM-1) in urine of patients with contrast- To understand the changes of β2-MG, NAG and KIM-1 in contrast-induced nephropathy patients and its relationship with renal function. Methods Forty-nine patients with contrast-related nephropathy were enrolled. At the same time, 52 healthy volunteers were enrolled. The levels of β2-MG, NAG and KIM-1 in urine were measured respectively by ELISA, and their relationship with renal function was analyzed . Results The urinary β2-MG, NAG and KIM-1 levels in patients with contrast-related nephropathy were (594.62 ± 87.93) mg / L and (24.52 ± 4.64) U / L and (4.68 ± 0.83) ng / The difference was statistically significant (P <0.05) in the healthy control group [β2-MG (108.16 ± 10.55) mg / L, NAG (8.74 ± 1.75) U / L and KIM-1 (0.28 ± 0.10) ng / ). The creatinine clearance rate (Ccr) in patients was (25.09 ± 7.50) ml / min, which was lower than that in healthy controls (83.75 ± 33.84) ml / min (P <0.05). Conclusion The levels of β2-MG, NAG and KIM-1 in urine of patients with contrast-related nephropathy were significantly higher than those in healthy controls, reflecting the damage of renal tubules and could be used as a detection index of renal function in patients with contrast-related nephropathy.