论文部分内容阅读
为改进Ｇｒａｖｅｓ眼病的疗效，作者对３５例病情较重或经常规治疗无效的患者，用地塞米松、氨甲喋呤静脉注射或点滴，每周１次，连续４周，并同服小剂量强的松（Ｐ）５日疗法／周，４周后加服硫唑嘌呤（Ａ）或６硫基嘌呤（６ＭＰ）。６周为一疗程，若病情需要，可重复１个疗程，然后用Ｐ＋Ａ巩固治疗并逐渐减量至第６月停药。结果：３３（９４．３％）例眼部症状改善，其眼球突度减少，与治前相比有显著性差异，突眼≤１年比＞１年者更明显。约半数闭目不全和复视者，以及５例暴露性角膜炎及２例溃疡穿孔者经治愈，仅留角膜云翳。未见严重毒副反应
To improve the efficacy of Graves ophthalmopathy, the author of 35 patients with severe disease or conventional treatment ineffective patients with dexamethasone, methotrexate intravenously or drip once a week for 4 weeks and with a small dose of prednisone P) Day 5 therapy / week, add azathioprine (A) or 6thiopurine (6MP) after 4 weeks. 6 weeks for a course of treatment, if the condition needs, repeat 1 course of treatment, and then use P + A consolidation therapy and gradually reduced to the first 6 months withdrawal. Results: In 33 (94.3%) cases, the symptoms of the eye were improved and the degree of ophthalmia was decreased. There was a significant difference compared with that before the treatment. The patients with exophthalmos ≤ 1 year were more obvious than> 1 year. About half of the patients with retinopathy and diplopia, as well as 5 cases of keratitis and 2 cases of ulcer perforation were cured, leaving only the cornea. No serious side effects