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在许多临床情况下,鉴定胎儿ABO血型是重要的,比如产前预报与ABO位点连锁的指甲-膑骨综合征等遗传病,以及检查胎-母血型是否配合等。 Fuchs等人(1956)曾采用胎儿羊水细胞与ABO型已知的红细胞做混合凝集试验来鉴定胎儿ABO血型。但Broussy等人(1958)认为,该凝集反应太弱,易导致错误结果。Philip等人(1978)使用胎儿镜检查时采集胎儿血样鉴定血型。但采集胎儿血样比较困难,而且易被母体血液污染。由于ABH物质产生于胎儿发育早期,羊水中累积的ABH物质可被血凝抑制试验检出,因此测定可溶性ABH物质,提供了检查胎儿血型的另一方法。过去一般认为该试验只适用于分泌型胎儿,但作者发现非分
In many clinical settings, it is important to identify the fetal ABO blood group, such as genetic diseases such as nails-tarsal syndrome linked to the ABO site in prenatal prediction, and to check if the fetus-maternal blood type is compatible. Fuchs et al. (1956) used a mixed agglutination test using fetal amniocytes and ABO-type erythrocytes to identify fetal ABO blood groups. But Broussy et al (1958) that the agglutination reaction is too weak, easily lead to wrong results. Philip et al. (1978) collected fetal blood samples for the identification of blood groups using the Fetal Examination. However, fetus blood samples collected more difficult, and easily contaminated by maternal blood. Since ABH substances are produced during the early stages of fetal development, ABH accumulations in amniotic fluid can be detected by the hemagglutination inhibition test, thus measuring soluble ABH substances and providing another means of examining the fetal blood type. In the past generally considered the test applies only to secretory fetuses, but the authors found that non-points