帕金森病是发生于中年以上的神经系统常见病,近年来基因治疗帕金森病显示了其良好的潜力和发展前途。基因治疗帕金森病采用两种策略:其一是将酶基因如TH、AADC、GTPCH基因直接或间接地导入脑内以增加DA的合成,其二为导入神经营养因子基因以保护DA能神经元。病毒载体或非病毒载体均被采用。本文对目前基因治疗帕金森病的具体方法作一综述。 Parkinson’s disease is a common disease of the nervous system that occurs in middle-aged people. In recent years, gene therapy of Parkinson’s disease has shown its good potential and development prospects. Gene therapy for Parkinson’s disease using two strategies: one is the enzyme gene such as TH, AADC, GTPCH gene directly or indirectly into the brain to increase the synthesis of DA, the second is the introduction of neurotrophic factor gene to protect DA neurons . Both viral and non-viral vectors are used. This article reviews the current methods of gene therapy for Parkinson’s disease.