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目的:判断胰尿蛋白酶原-2(尿TPG-2)诊断急性胰腺炎的价值。方法:比较急性胰腺炎起病4 h内、4～120 h之间以及120 h后尿TPG-2和血清淀粉酶的阳性率,了解尿TPG-2诊断急性胰腺炎的敏感性。比较在其他急腹症时,尿TPG-2和血清淀粉酶的阳性率,了解尿TPG-2诊断急性胰腺炎的特异性。结果:起病4 h内患者75例,蛋白酶原-2阳性51例(68%),血清淀粉酶阳性39例(52%),尿TPG-2阳性率高于血清淀粉酶阳性率(P<0.05)。起病4-120 h之间,患者211例,尿TPG-2阳性204例(96.7%),血清淀粉酶阳性199例(94.3%),尿TPG-2阳性率和血清淀粉酶阳性率之间无差异(P>0.05)。起病120 h之后,患者211例,蛋白酶原-2阳性97例(46.0%),血清淀粉酶阳性62例(29.4%),尿TPG-2阳性率高于血清淀粉酶阳性率(P<0.05)。肠梗阻、胆系结石以及十二指肠球部溃疡所构成的急腹症45例,尿TPG-2阳性11例(24.4%),血清淀粉酶阳性4例(8.9%),尿TPG-2阳性率和血清淀粉酶阳性率之间无显著差异(P>0.05)。结论:尿TPG-2是诊断急性胰腺炎的可靠指标,早期与回顾性诊断急性胰腺炎,较血清淀粉酶敏感。
Objective: To determine the value of pancreatic procaspase-2 (TPG-2) in the diagnosis of acute pancreatitis. Methods: The positive rates of urinary TPG-2 and serum amylase in 4 h, 4 to 120 h, and 120 h after onset of acute pancreatitis were compared, and the sensitivity of urinary TPG-2 in the diagnosis of acute pancreatitis was analyzed. Compare the positive rate of urinary TPG-2 and serum amylase in other acute abdomen, understand the specificity of urinary TPG-2 in diagnosis of acute pancreatitis. Results: 75 cases were diagnosed within 4 hours after onset, 51 cases (68%) were positive for protease-2 and 39 cases (52%) were positive for serum amylase. The positive rate of TPG-2 in urine was higher than that of serum amylase (P < 0.05). Between onset 4-120 h, 211 patients, 204 urinary TPG-2 positive (96.7%), serum amylase-positive 199 cases (94.3%), urinary TPG-2 positive rate and serum amylase positive rate No difference (P> 0.05). After 120 h of onset, the positive rate of TPG-2 in urine was higher than that of serum amylase (211 cases) (P <0.05) in 211 cases, 97 cases (46.0%) of protease-2 positive, 62 cases ). 45 cases of acute abdomen consisting of intestinal obstruction, gallstones and duodenal ulcer, urine TPG-2 positive in 11 cases (24.4%), serum amylase positive in 4 cases (8.9%), urine TPG-2 There was no significant difference between the positive rate and the positive rate of serum amylase (P> 0.05). Conclusion: Urinary TPG-2 is a reliable indicator of acute pancreatitis. Early and retrospective diagnosis of acute pancreatitis is more sensitive than serum amylase.