报告3例对唑类抗真菌药物耐药的顽固性外阴阴道念珠菌病。3例病人年龄分别为38、31、42岁。病史分别为3、2、5年。均有持续或反复发作的阴道分泌物增多、瘙痒、性交困难、排尿困难及外阴刺激症状,月经前加重,阴道棉拭子镜检见大量的酵母菌,培养为光滑念珠菌,治疗情况如下。例1.以制霉菌素和唑类抗真菌药口服及局部联合应用后又单独应用氟康唑治疗皆无效。而用伊曲康唑200mg,每日2次,口服 Report of 3 cases of azole antifungal drug resistant refractory vulvovaginal candidiasis. Three patients were 38, 31, 42 years old. Medical history were 3, 2, 5 years. Have persistent or recurrent seizures increased vaginal discharge, itching, difficult sexual intercourse, dysuria and vulvar irritation, increased menstrual, vaginal cotton swab microscopic examination of a large number of yeast, culture of Candida glabra, the treatment is as follows. Example 1. The combination of nystatin and azole antifungal agents after oral and topical application of fluconazole alone were ineffective. With itraconazole 200mg, 2 times a day, orally