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目的探讨血浆同型半胱氨酸(Hcy)代谢酶亚甲基四氢叶酸还原酶(MTHFR)C677T基因多态性与缺血性脑卒中的相关性。方法共纳入研究者162例,其中脑梗死患者102例,对照组60例为健康体检者,所有患者均经颅脑磁共振(MRI)检查。采用全自动基因芯片检测MTHFR C677T位基因型。结果脑梗死组MTHFR C677T突变(TT)基因型及T等位基因频率高于对照组(χ2=16.0655,P=0.0003;χ2=14.4755,P=0.0001)。结论 MTHFR C677T位点C→T基因突变可能是缺血性脑卒中的危险因素。
Objective To investigate the relationship between plasma homocysteine (Hcy) metabolism enzyme methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and ischemic stroke. METHODS: A total of 162 investigators were enrolled in this study. Among them, 102 patients were cerebral infarction and 60 patients in control group were healthy. All patients underwent MRI (magnetic resonance imaging) examination. Automated gene chip MTHFR C677T genotype was detected. Results The MTHFR C677T mutation (TT) genotype and T allele frequency of cerebral infarction group were higher than those of control group (χ2 = 16.0655, P = 0.0003; χ2 = 14.4755, P = 0.0001). Conclusion Mutation of C → T gene at MTHFR C677T site may be a risk factor for ischemic stroke.