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目的探讨平阳霉素+地塞米松局部注射治疗婴幼儿血管瘤的疗效。方法将平阳霉素8 mg+地塞米松5 mg+2%利多卡因1~2 ml+生理盐水3~8 ml稀释后,行血管瘤内注射至肿胀发白为限,1次平阳霉素用量不超过8 mg。观察2周,视瘤体颜色及硬度决定是否继续用药,直至瘤体开始变硬萎缩为止,平阳霉素注射总量不超过40 mg。近两年来,用该方法治疗1~8个月龄婴幼儿体表增生期血管瘤36例,其中颜面部24例,胸部3例,背部2例,上肢5例,足2例;草莓状血管瘤30例,混合型血管瘤6例。血管瘤最小面积0.6 cm×1.2 cm,最大面积23.0 cm×12.0 cm。结果1次注射治愈2例,2~3次注射治愈25例,4~5次治愈9例,其中局部坏死1例(为足背足底大面积草莓状血管瘤),经换药及手术愈合。随访6~19个月,未见复发,除1例遗留瘢痕外,其余全部无瘢痕愈合。有效率达100%。结论平阳霉素+地塞米松局部注射治疗婴幼儿血管瘤,具有疗效显著、简便易行、安全可靠等优点,是治疗增生期血管瘤首选方法之一,值得推广。
Objective To investigate the curative effect of local injection of pingyangmycin + dexamethasone on infantile hemangiomas. Methods Pingyangmycin 8 mg + dexamethasone 5 mg + 2% lidocaine 1 ~ 2 ml + normal saline 3 ~ 8 ml diluted hemangioma injection to swelling and whitening is limited to 1 dose of pingyangmycin not More than 8 mg. Observation 2 weeks, depending on tumor color and hardness decide whether to continue medication until the tumor began to harden atrophy, the total amount of pingyangmycin injection does not exceed 40 mg. In the past two years, this method was used to treat 36 cases of hyperplastic hemangiomas of 1 to 8 months of age in infants and young children, including 24 cases of facial, 3 cases of thoracic, 2 cases of back, 5 cases of upper limb and 2 cases of foot. 30 cases of tumor, mixed hemangioma in 6 cases. The minimum area of hemangiomas is 0.6 cm × 1.2 cm and the maximum area is 23.0 cm × 12.0 cm. Results 1 injection cured 2 cases, 2 to 3 times injection cured 25 cases, 4 to 5 times cured 9 cases, including local necrosis in 1 case (for large dorsal plantar hemangiomas), after dressing and operation healing . All the patients were followed up for 6-19 months. No recurrence was found. All the remaining scar except one remained scar. Effective rate of 100%. Conclusion Pingyangmycin + dexamethasone local injection for the treatment of infantile hemangiomas, with a significant effect, easy, safe and reliable, is one of the preferred method of treatment of proliferative hemangioma, it is worth promoting.