靶向肿瘤细胞表面抗原的免疫毒素 ,可释放特异毒素到肿瘤细胞 ,而不伤害正常细胞。一旦毒素进入细胞 ,则通过其抑制蛋白合成或改变信号传递途径而杀死肿瘤细胞。血液系统恶性肿瘤是免疫毒素的最佳治疗对象 ,通常此种肿瘤表面标记呈高表达 ,且易于与药物结合。最早的免疫毒素之 Immunotoxins, which target tumor cell surface antigens, release specific toxins to tumor cells without damaging normal cells. Once the toxin enters the cell, the tumor cell is killed by its inhibition of protein synthesis or alteration of the signaling pathway. Hematological malignancies are the best therapeutic targets for immunotoxins. Usually, such tumor surface markers are highly expressed and easily combined with drugs. The earliest immune toxin