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多柔比星(doxorubicin,DOX)属蒽醌类抗肿瘤抗生素,具有抗瘤谱广、抗瘤作用强的特点,在临床上广泛用于治疗多种恶性肿瘤,但DOX对心肌具有毒性损伤作用[1]。心肌细胞铁代谢平衡是维持心肌细胞生理功能的重要因素。DOX致心肌细胞铁超载使心肌细胞产生活性氧(reactiveoxygen specie
Doxorubicin (DOX) is an anthraquinone antitumor antibiotic with broad spectrum anti-tumor effect and strong anti-tumor effect. It is widely used in clinical treatment of many malignant tumors, but DOX has a toxic effect on myocardial injury [1]. Iron metabolism of myocardial cells is an important factor to maintain the physiological function of cardiomyocytes. DOX induces cardiomyocytes to produce reactive oxygen species (ROS) via iron overload