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目的 以数字连接试验(NCT)检测慢性肝病尤其是病毒性肝炎患者的亚临床肝性脑病(SHE)发病率,以了解肝功能与SHE的关系。方法 对177例慢性肝病进行NCT检测。结果 慢性肝病患者的NCT异常率31.1％(55/177),病毒性肝炎患者的NCT异常率29.7％(47/158);肝功损害轻度及重症肝炎时,肝硬化组与非肝硬化组的NCT异常率无差别,肝功损害中度和重度时,肝硬化组的异常率高于非肝硬化组,且有显著性差异;肝功分级间的SHE发病率无差异;男女间的NCT异常率无差别。结论 肝病病人出现智力障碍与肝功损害及肝硬化的门体分流都有关,而与病因无关;肝功损害程度与SHE的发生率末显示线性关系。
Objective To detect the incidence of subclinical hepatic encephalopathy (SHE) in patients with chronic liver disease, especially viral hepatitis, by digital connection test (NCT) to understand the relationship between liver function and SHE. Methods 177 cases of chronic liver disease NCT test. Results The abnormality rate of NCT in patients with chronic liver disease was 31.1% (55/177) and the abnormal rate of NCT in patients with viral hepatitis was 29.7% (47/158). In patients with mild and severe hepatitis with liver damage, patients with cirrhosis and non-cirrhosis Of NCT abnormal rate was no difference between the moderate and severe liver damage, cirrhosis of the abnormal rate was higher than non-cirrhosis group, and there was a significant difference; liver function grading between the incidence of SHE no difference between male and female NCT Abnormal rate no difference. Conclusions Mental disorders in patients with liver diseases are related to liver damage and portal shunt of liver cirrhosis, but have no relationship with etiology. The degree of liver damage shows a linear relationship with the incidence of SHE.