AIM: To evaluate the efficacy and safety of endoscopicsubmucosal dissection(ESD) for early gastric cancer(EGC) with undifferentiated-type histology.METHODS: A systematic literature review was conducted using the core databases. Complete resection,curative resection, en bloc resection, recurrence and adverse event rate were extracted and analyzed. A random effect model was applied. The methodological quality of the enrolled studies was assessed using the Newcastle-Ottawa Scale. Publication bias was evaluated using a funnel plot, the trim and fill method, Egger’s test,and a rank correlation test.RESULTS: Fourteen retrospective studies between2009 and 2014 were identified(972 EGC lesions with undifferentiated-type histology). The total en bloc and complete resection rates were estimated as92.1%(95%CI: 87.4%-95.2%) and 77.5%(95%CI:69.3%-84%), respectively. The total curative resection rate was 61.4%(95%CI: 44.5%-75.9%). The overall recurrence rate was 7.6%(95%CI: 3.4%-16%).Limited to histologically diagnosed expanded-criteria lesions, the en bloc and complete resection rates were91.2% and 85.6%, respectively. The curative resection rate was 79.8%.CONCLUSION: In this analysis, ESD is a technically feasible treatment modality for EGC with undifferentiatedtype histology. Long-term studies are needed to confirm these therapeutic outcomes. AIM: To evaluate the efficacy and safety of endoscopicsubmucosal dissection (ESD) for early gastric cancer (EGC) with undifferentiated-type histology. METHODS: A systematic literature review conducted using the core databases. Complete resection, curative resection, en bloc resection, A random effect model was applied. The methodological quality of the enrolled studies was assessed using the Newcastle-Ottawa Scale. The published bias was evaluated using a funnel plot, the trim and fill method, Egger’s test , and a rank correlation test .RESULTS: Fourteen retrospective studies between 2009 and 2014 were identified (972 EGC lesions with undifferentiated-type histology). The total en bloc and complete resection rates were estimated as 92.1% (95% CI: 87.4% The overall recurrence rate was 61.4% (95% CI: 44.5% -75.9%). The overall recurrence rate was 7.6% (95% CI 95.2%) and 77.5% (95% CI 69.3% CI: 3.4% -16%). Limited to histo logically diagnosed expanded-criteria lesions, the en bloc and complete resection rates were 91.2% and 85.6%, respectively. The curative resection rate was 79.8% .CONCLUSION: In this analysis, ESD is a technically feasible treatment modality for EGC with undifferentiated type histology Long-term studies are needed to confirm these therapeutic outcomes.