椎间盘退行性疾病(intervertebral disc degenerative disease,IDDD)是目前临床上的常见病,其治疗手段多样,但其发病机制以及变化规律仍不清楚,国内外学者为探寻椎间盘退变规律构建了多种椎间盘退变(intervertebral disc degeneration,IDD)动物模型,按照模型建立方法可大致分为力学模型、损伤模型、生物学模型。但在临床中因椎间盘直接损伤或生物源性椎间盘退变所致腰痛的患者较 Intervertebral disc degenerative disease (IDDD) is a common clinical disease, the treatment of a variety of ways, but its pathogenesis and changes in the law is still not clear, domestic and foreign scholars to explore the law of disc degeneration built a variety of intervertebral disc Degeneration (intervertebral disc degeneration, IDD) animal model, according to the model can be divided into mechanical model, damage model, biological model. But in clinical patients with direct or indirect disc degeneration caused by low back pain compared with patients