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目的 探讨梅毒患者各期病程中血清可溶性白介素 2受体 (SIL - 2R)的水平及临床意义。方法 采用酶联免疫吸附法 (ELSA)测定 70例梅毒患者及其治疗后SIL - 2R水平 ,并与 2 0名健康体检者进行比较。结果 所有梅毒患者血清SIL - 2R的水平明显高于正常对照组 ,两组间差异有显著性 (P <0 0 5 ) ;二期和潜伏梅毒患者血清SIL - 2R的水平高于一期梅毒 (P <0 0 5 )。青霉素治疗后 ,判为治疗有效者 ,测定SIL - 2R的水平 ,比正常组略高 ,两者无显著性差异 (P >0 0 5 )。结论 SIL - 2R水平的测定对梅毒病理判定及监测治疗效果有一定的参考价值。
Objective To investigate the serum levels of soluble Interleukin - 2 Receptor (SIL - 2R) in patients with syphilis and its clinical significance. Methods Serum levels of SIL - 2R in 70 patients with syphilis were measured by enzyme - linked immunosorbent assay (ELISA) and compared with 20 normal controls. Results The levels of serum SIL - 2R in all patients with syphilis were significantly higher than those in normal controls (P <0.05). The levels of serum SIL - 2R in patients with secondary and latent syphilis were higher than those of patients with primary syphilis P <0 0 5). After penicillin treatment, the patients were judged to be effective and the level of SIL - 2R was measured, which was slightly higher than that of normal group. There was no significant difference between the two groups (P> 0.05). Conclusion The determination of SIL - 2R level has certain reference value on the pathological determination of syphilis and the monitoring and treatment effect.