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A 67-year-old man sequentially developed anti-Ma2-assoc-iated Paraneoplastic encephalitis(PNE)and contralateral herpes simplex encephalitis(HSE).Brain biopsy 1 month before HSE revealed extensive infiltrates of T cells,B cells,and plasma cells.Most T cells expressed the cytotoxic granule-associated protein TIA-1 and the membranolytic protein granzyme-B.Although recovery was thought to be unlikely,treatment of the PNE with corticosteroids and resection of the associated lung cancer resulted in dramatic improvement for 21 months.
A 67-year-old man previously developed anti-Ma2-assoc-iated Paraneoplastic encephalitis (PNE) and contralateral herpes simplex encephalitis (HSE). Brain biopsy 1 month before HSE revealed extensive infiltrates of T cells, B cells, and plasma cells. Most T cells expressed the cytotoxic granule-associated protein TIA-1 and the membranolytic protein granzyme-B. Although recovery was thought to be unlikely, treatment of the associated lung cancer resulted in dramatic improvement for 21 months.