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作者在25倒成人ALL中(其中24例为非B非T型)做了染色体研究,7例发现有Ph~1存在(28%)。Ph~1(+)细胞百分数取决于疾病不同时期,确诊时为50～100%,而部分缓解时则为16～42%。Bloomfield等报告20例成人ALL,Ph~1阳性率25%。而儿童ALL仅为2～3%。本文7例中6例做了G、C区带研究,3例为CGL典型Ph~1,即22号染色体长臂移位于9号染色体上[t(9~(+);22q~(-))];其余3例,2个9号染色体都正常,其中一例22号染色体断下的长臂未能移位于任何其它染色体上(22q~(-)),另一例可能移位于1号染色体短臂上(t(1,
The authors performed chromosomal studies in 25 adult ALL patients (24 of whom were non-B non-T-type) and Ph-1 was found in 7 (28%). The percentage of Ph ~ 1 (+) cells depends on the disease at different stages, between 50 and 100% at diagnosis and between 16 and 42% at partial remission. Bloomfield and other reports 20 cases of adult ALL, Ph ~ 1 positive rate of 25%. While children with ALL only 2 to 3%. In this paper, 6 cases of G and C were studied in 6 cases, 3 cases of CGL typical Ph ~ 1, that is, long arm of chromosome 22 shifted to chromosome 9 [t (9 ~ (+); 22q ~ (- )); The remaining three cases, two on chromosome 9 are normal, one case of chromosome 22 off the long arm failed to shift to any other chromosome (22q ~ (-)), another case may be shifted to 1 Chromosome short arm (t (1,