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背景:将高血压脑血管病研究中建立的6项新指标运用到短暂性脑缺血发作(Transientischemicattack,TIA)诊断研究中,能对原检测指标不能反映的全脑11条血管的整体的质与量的状况有较准确的评价。目的:探讨经颅多普勒新指标对TIA的评估价值,弥补了原指标的不足。设计:以诊断为依据的病例对照研究。地点、对象和方法:116例研究对象均为解放军第三二三医院收治的TIA患者(TIA组)和同期98例体检的健康者,采用与计算机连用的方法,对两组214例受试者2354条脑血管进行新旧指标的对照检测。主要观察指标:两组经颅多普勒检测新、原指标比较。结果:用经颅多普勒新指标检测,在无明显脑功能损坏情况下,116例中110例(94.8%)异常,20例(18.1%)为颈内动脉系统血流速度改变。正常组与TIA组原指标比较:TIA组的搏动指数增高,椎基底动脉的脑血管收缩期、舒张期流速明显减慢,颈内动脉系统血流速度减低;与正常组相比,差异有差异性意义(t=1.97～2.89,P<0.05;t=3.1～11.59,P<0.01);频谱形态可见收缩波圆钝,S2>S1,峰时后延。正常组与TIA组新指标比较:TIA组中81.8%椎基底动脉血流异常者的反弹高度、紧张度、平均收缩速度、缓慢指数明显降低,压力指数、脑血管负荷指数增高。TIA组中的18.2%颈内动脉系统血流速度减低者的反弹高度、紧张度
BACKGROUND: Six new indices established in the study of hypertensive cerebrovascular disease were applied in the diagnosis of transient ischemic attack (TIA), which can not reflect the overall quality of 11 blood vessels in the brain And the status of the amount of more accurate evaluation. Objective: To explore the value of transcranial Doppler assessment of new indicators of TIA to make up for the lack of the original indicator. Design: A case-control study based on diagnosis. Location, Subjects and Methods: Totally 116 TIA patients (TIA group) and 98 healthy subjects were enrolled in the Twenty-third Hospital of PLA. All subjects were enrolled in this study. Two groups of 214 subjects 2354 cerebrovascular contrast test of old and new indicators. MAIN OUTCOME MEASURES: Two groups of transcranial Doppler detection of new and original indicators comparison. Results: With transcranial Doppler, a new index was detected in 110 cases (94.8%) of 116 cases without abnormality of brain function, and 20 cases (18.1%) of them were changes of blood flow velocity in internal carotid artery. Compared with the normal group, the pulsatility index of TIA group increased, the vasoconstriction velocity and diastolic velocity of vertebrobasilar artery decreased significantly, and the velocity of blood flow in the internal carotid artery decreased. Compared with the normal group, the difference was significant (T = 1.97 ~ 2.89, P <0.05; t = 3.1 ~ 11.59, P <0.01). The spectrum shows that the contractile wave is blunt, S2> S1, and the peak is delayed. Compared with the new indexes of TIA group, the rebound height, tension, average contraction velocity, slow index of 81.8% vertebrobasilar artery abnormalities in TIA group were significantly decreased, and the pressure index and cerebrovascular load index were increased. 18.2% of the TIA group internal carotid artery blood flow velocity decreased rebound height, tension