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目的:探讨神经母细胞瘤(NB)细胞增殖活性在 NB 恶性程度和预后判断中的价值。方法:应用免疫组化法对20例 NB 标本中增殖细胞核抗原(PCNA)表达进行检测。结果:PCNA 表达指数(PEI)与肿瘤重量、有丝分裂核碎裂指数(MKI)呈正相关,r 分别为0.664和0.903;与术后生存时间呈负相关,r=-0.919;年龄<1岁、临床早期(Ⅰ、Ⅱ期)及ⅣS期、神经节神经母细胞瘤(GNB)、Shimada 病理分型 F 型及肿瘤切除者,其 PEI 均低于相应组别,P 值分别为>0.05、<0.05、<0.05、<0.01、<0.05。结论:PCNA 的表达与 NB 的恶性增殖、生长及浸润密切相关,是 NB 细胞增殖活性增高的分子标志;PEI 对判断 NB 的恶性程度和预后具有重要价值。
Objective: To investigate the value of proliferative activity of neuroblastoma (NB) cells in malignancy and prognosis of NB. Methods: The expression of proliferating cell nuclear antigen (PCNA) in 20 specimens of NB was detected by immunohistochemistry. Results: The PCNA expression index (PEI) was positively correlated with tumor weight and mitotic nuclear fragmentation index (MKI), r were 0.664 and 0.903 respectively, and negatively correlated with postoperative survival time (r = -0.919) In the early stage (stageⅠ, Ⅱ) and stage ⅣS, ganglioneuroblastoma (GNB), Shimada pathological type F and tumor resection, the PEI were lower than the corresponding groups, P values were> 0.05, <0.05 , <0.05, <0.01, <0.05. CONCLUSION: The expression of PCNA is closely related to the malignant proliferation, growth and infiltration of NB, and is a molecular marker of NB cell proliferative activity. PEI is of great value in judging the malignancy and prognosis of NB.