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目的:探讨老年性2型糖尿病患者骨密度(BMD)及骨生化指标的变化情况,阐明老年性2型糖尿病患者骨质疏松症相关危险因素。方法:测定110例男性2型糖尿病患者和87例正常男性的BMD,并检测生化及骨代谢指标。结果:老年性2型糖尿病患者组BMD降低的发生率明显高于对照组(P<0.01),血清骨钙素(BGP),胰岛素(Ins)水平则显著低于对照组(P<0.01),尿脱氧吡啶啉(Dpd),空腹血糖(FPG)高于对照组(P<0.01)。结论:老年性2型糖尿病患者较正常人群易发生骨质疏松症,BMD、BGP、Dpd水平是诊断糖尿病性骨质疏松症(DOP)的重要指标,良好的血糖和血脂的调控及尽可能的保护胰岛β细胞可降低骨质疏松症的发生。
Objective: To investigate the changes of bone mineral density (BMD) and bone biochemical markers in elderly type 2 diabetic patients and to elucidate the risk factors associated with osteoporosis in senile type 2 diabetic patients. Methods: The BMD of 110 male patients with type 2 diabetes mellitus and 87 normal men were determined. Biochemical and bone metabolic parameters were measured. Results: The incidence of decreased BMD was significantly higher in the elderly patients with type 2 diabetes mellitus than in the control group (P <0.01). The levels of serum BGP and insulin were significantly lower than those in the control group (P <0.01) Urinary deoxypyridin (Dpd) and fasting plasma glucose (FPG) were higher than those of the control group (P <0.01). Conclusion: Osteoporosis is prone to occur in elderly patients with type 2 diabetes mellitus, and the level of BMD, BGP and Dpd are important indicators in the diagnosis of diabetic osteoporosis (DOP), and the regulation of blood glucose and blood lipids as much as possible Protection of pancreatic β cells can reduce the incidence of osteoporosis.