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目的探析老年男性2型糖尿病合并骨质疏松患者骨代谢生化指标的变化。方法选取2013年4月-2014年4月医院收治的年龄≥65岁的男性2型糖尿病合并骨质疏松的50例患者为观察组,另选取50例年龄≥65岁的无骨质疏松的2型糖尿病男性患者为对照组,采用双能X线骨密度仪对2组患者的股骨颈及L1~L4腰椎的骨密度进行测定,并同时检测2组患者的空腹血磷、血钙、甲状旁腺激素(PTH)、血清骨钙素(BGP)、碱性磷酸酶(ALP)和晨尿中脱氧吡啶啉(DPD)的含量。结果观察组患者股骨颈的平均骨密度与腰椎的平均骨密度均明显低于对照组,差异有统计学意义(P<0.05)。2组患者在血清磷(P)、血清钙(Ca)及碱性磷酸酶(ALP)含量的差异无统计学意义(P>0.05)。但观察组患者的甲状旁腺激素(PTH)和晨尿中脱氧吡啶啉(DPD)的含量明显高于对照组(P<0.05);观察组的血清骨钙素(BGP)水平明显低于对照组,差异均有统计学意义(P<0.05)。结论 2型糖尿病合并骨质疏松的老年男性患者其骨形成的能力降低,骨吸收功能亢进,在治疗2型糖尿病的过程中,应及时检测患者的骨密度,对于骨质疏松做到有效防治。
Objective To explore the changes of biochemical markers of bone metabolism in elderly men with type 2 diabetes mellitus and osteoporosis. Methods Fifty patients with type 2 diabetes mellitus and osteoporosis who were admitted to our hospital from April 2013 to April 2014 were enrolled in the study. Fifty patients with osteoporosis, age ≥65 years, were selected as observation group Type diabetes mellitus as the control group. The bone mineral density of the femoral neck and L1 ~ L4 lumbar spine were measured by dual-energy X-ray absorptiometry in two groups. At the same time, the fasting blood phosphorus, serum calcium and parathyroid (PTH), serum BGP, alkaline phosphatase (ALP) and deoxypyridinoline (DPD) in morning urine. Results The average femoral neck BMD and lumbar BMD in observation group were significantly lower than those in control group (P <0.05). There was no significant difference in serum phosphorus, calcium and alkaline phosphatase (ALP) between the two groups (P> 0.05). However, the levels of parathyroid hormone (PTH) and deoxy-pyridinoline (DPD) in the morning urine of the observation group were significantly higher than those of the control group (P <0.05). The serum BGP level of the observation group was significantly lower than that of the control group Group, the difference was statistically significant (P <0.05). Conclusion The elderly male patients with type 2 diabetes mellitus and osteoporosis have lower ability of bone formation and bone resorption. In the treatment of type 2 diabetes mellitus patients should be tested for bone mineral density in time and effective for prevention and treatment of osteoporosis.