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将181例服用他巴唑(MMI)的甲亢患者分为:10mg,3/d(A);30mg 顿服(B);5mg,3/d(C);15mg 顿服(D);10mg/d(E).结果 A～D 组甲状腺功能恢复正常所需的时间分别为4.1±1.5,3.9±1.3,4.3±1.6和4.3±1.7周,无显著差异,E 组(7.8±2.1周)显著长于其他各组。67例 PD 试验表明15mgMMI 抑制碘的有机化作用与30mg 者相似,可维持24h。C,D 组(14.9%)与 E 组(5.6%)不良反应明显少于 A,B 组(38.2%)。以上结果提示15mg/dMMI 是治疗甲亢理想剂量,每日一次顿服的疗法合理有效。
181 hyperthyroid patients taking methimazole (MMI) were divided into 10 mg, 3 / d (A), 30 mg Dayton (B), 5 mg, d (E) .Results The time required for normal thyroid function recovery in groups A to D was 4.1 ± 1.5, 3.9 ± 1.3, 4.3 ± 1.6 and 4.3 ± 1.7 weeks respectively, with no significant difference in group E (7.8 ± 2.1 weeks) Longer than the other groups. 67 cases of PD test showed that 15mgMMI inhibition of iodine and 30mg similar to the role of organism, can be maintained 24h. Adverse reactions of Group C and D (14.9%) and Group E (5.6%) were significantly less than those of Group A and B (38.2%). The above results suggest that 15mg / dMMI is the ideal dose for the treatment of hyperthyroidism, Dayton daily treatment is reasonable and effective.