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多形红斑(EM)是皮肤粘膜的急性自身限制性疾病。轻型EM 1岁以下的婴儿中发病已有过报道;重症EM及中毒性上皮溶解坏死(toxic epidermal necrolysis,TEN)在3个月以下的婴儿中发病的报道却很少见。本文报告1例2个月婴儿感染人类免疫缺陷病毒(HIV)并重症EM。病例:黑人男孩,2个月,因红色斑疹,伴发热、双侧结膜炎3天入院。发病前曾服用苯巴比妥和澳化哌苯偶酯糖浆。白细胞计数7900×10~9/L,胸部X线正常,血、尿、脑背液培养无细菌生长。鼠疫、麻疹和小RNA病毒等血清试验均阴性;单纯疱疹和水痘带状疱疹病毒血清检查及培养阴性。
Erythema multiforme (EM) is an acute, self-limiting disease of the skin and mucous membranes. The incidence of mild EM in infants younger than 1 year has been reported; severe EM and toxic epidermal necrolysis (TEN) are rare in infants less than 3 months old. This article reports 1 case of 2-month-old infants infected with human immunodeficiency virus (HIV) and severe EM. Case: Black boy, 2 months, admitted to hospital for 3 days due to red rash, fever, bilateral conjunctivitis. Before taking the disease had taken phenobarbital and Australian Piphenyl ester syrup. White blood cell count 7900 × 10 ~ 9 / L, chest X-ray normal, blood, urine, brain dorsal fluid culture without bacterial growth. Serogroups such as plague, measles and picornavirus were negative; herpes simplex and varicella zoster virus serological tests and culture negative.