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对连续就诊的220例慢性胃炎患者进行幽门螺杆菌(HP)检测和胃粘膜活检病理学检查。结果显示HP阳性率为58.7%,HP阳性患者胃粘膜腺体萎缩和肠上皮化生(肠化生)的发生率及严重程度均显著高于HP阴性患者;肠化生分型表明Ⅱ型和Ⅲ型肠化生更多见于HP阳性患者;流式细胞术分析表明HP阳性患者胃粘膜细胞的S期比率和增殖指数均显著高于HP阴性患者。提示HP感染可能通过刺激胃粘膜细胞的增殖加速、更新加快,从而加速了胃粘膜腺体萎缩和肠化生的形成与发展,继而增加了患胃癌的危险性。
Helicobacter pylori (HP) and gastric mucosal biopsy were performed on 220 consecutive patients with chronic gastritis. The results showed that the positive rate of HP was 58.7%. The incidence and severity of gastric mucosal glandular atrophy and intestinal metaplasia (intestinal metaplasia) in HP positive patients were significantly higher than those in HP negative patients. Type and type Ⅲ intestinal metaplasia more seen in HP-positive patients; flow cytometry analysis showed that HP-positive gastric mucosal cells S phase ratio and proliferation index were significantly higher than the HP-negative patients. Tip HP infection may accelerate the proliferation of gastric mucosal cells, update accelerated, thereby accelerating the gastric mucosal gland atrophy and intestinal metaplasia formation and development, and then increased the risk of gastric cancer.