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探讨胃粘膜淋巴滤泡与幽门螺杆菌感染之间的关系。409例胃镜检查患者作胃粘膜幽门螺杆菌培养、组织病理学检查,并进行病例对照研究。结果:胃粘膜内淋巴滤泡的出现与幽门螺杆菌感染有显著相关性,比数比为3.1(95%CI为2.1~4.8),出现≥3个淋巴滤泡时比数比则为7.7(95%CI为2.5~23.4),且不受患者年龄、性别的影响。淋巴滤泡与其它组织病理学改变:炎症程度、炎症活动性及萎缩性改变有显著相关性,与肠化生则无相关性。提示幽门螺杆菌感染可能是胃粘膜内淋巴滤泡形成的主要原因。
To investigate the relationship between gastric mucosal lymphoid follicles and Helicobacter pylori infection. 409 cases of gastroscopy for gastric mucosal Helicobacter pylori culture, histopathological examination, and case-control study. Results: The incidence of gastric mucosal lymphatic follicles was significantly correlated with Helicobacter pylori infection, the odds ratio was 3.1 (95% CI 2.1 ~ 4.8), there were ≥3 lymphoid follicles The odds ratio was 7.7 (95% CI, 2.5 to 23.4), independent of patient age and gender. Lymphatic follicles and other histopathological changes: the degree of inflammation, inflammatory activity and atrophic changes have a significant correlation with intestinal metaplasia was not related. Tip Helicobacter pylori infection may be the main reason for the formation of gastric mucosal lymphatic follicles.