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采用生物电子等排模拟法，用苯甲酰胺的结构代替抗肿瘤候选药物GSK2126458结构中吡啶与水的复合物，设计、合成了一系列2-取代-3-磺酰氨基-5-(6-喹唑啉基等)苯甲酰胺类化合物，采用1H NMR、13C NMR和HRMS表征目标化合物的结构。
基于生物电子等排法发现新型PI3K抑制剂:2-甲氧基-3-磺酰氨基-5-6-喹唑啉基)苯甲酰胺类
【摘 要】
：
采用生物电子等排模拟法，用苯甲酰胺的结构代替抗肿瘤候选药物GSK2126458结构中吡啶与水的复合物，设计、合成了一系列2-取代-3-磺酰氨基-5-(6-喹唑啉基等)苯甲酰胺类化合物，采用1H NMR、13C NMR和HRMS表征目标化合物的结构。
【机 构】
：
西安交通大学医学部药学院,西安 710061 上海医药工业研究院药理评价中心,上海
【出 处】
：
全国药物化学学术会议暨第四届中英药物化学学术会议
【发表日期】
：
2013年11期
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