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5. Novel small molecule inhibitors slow tumor growth by targeting GLUT1 and GLUT3

Novel small molecule inhibitors slow tumor growth by targeting GLUT1 and GLUT3

来源 :第十一届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：harryxu200x

【摘 要】

：

The human glucose transporter 1(GLUT1) is a facilitative membrane transporter,catalyzing the basal-level uptake of glucose.In the Wabberg effect,GLUT1 is overexpressed in many cancer cells,sometimes a

【作 者】

：

Meng Gao Jian Huang Xin Jiang Yafei Yuan Chengbo Yao Zuwan Lin Nieng Yan Hang Yin 

【机 构】

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School of Pharmaceutical sciences,Tsinghua University,Beijing,China,100082

【出 处】

：

第十一届全国化学生物学学术会议

【发表日期】

：

2019年3期

【关键词】

：

Glucose transporter Inhibitor Aerobic glycolysis cancer cell proliferation 

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　　The human glucose transporter 1(GLUT1) is a facilitative membrane transporter,catalyzing the basal-level uptake of glucose.In the Wabberg effect,GLUT1 is overexpressed in many cancer cells,sometimes accompanied with overexpression of GLUT3,transporting major glucose for cancer cells to survive and proliferate.

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