【摘 要】
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Purpose:Recentadvances inhigh-resolutionblackbloodMRIimaging(BBMRI)haveenabledthereliabledetectionandcharacterizationofintracranialatheroscleroticdisease(ICAD).Wesoughttodetermi
【出 处】
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中华放射学学术大会2016、中华医学会第23次全国放射学学术大会暨中华医学会第24次全国影像技术学术大会
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Purpose:Recentadvances inhigh-resolutionblackbloodMRIimaging(BBMRI)haveenabledthereliabledetectionandcharacterizationofintracranialatheroscleroticdisease(ICAD).WesoughttodeterminethereliabilityofthistechniquetodeterminetheprogressionofICADinanasymptomaticpopulation.Materials and Methods:Twenty-threeasymptomaticparticipants(9male;meanage,79.2years,ranges,71to86)withidentifiedICADwererecruitedfromapopulation-basedstudy,whounderwenthighresolutionvesselwallMRI.AllbaselineMRIwasperformedata3TSiemensscannerwithastandardizedbrainMRIprotocolthatconsistedofa3Dtime-of-flightMRAand3DhighisotropicresolutionBBMRI.TherepeatedMRIwasperformedona3TPhilipsscannerwithmeantimeintervalof2.3±0.49yearssincebaseline.TwoMRIprotocolswerematchedwithacquiredresolution(TOF,0.5mmx0.5mmx0.55m;BBMRI,0.5isotropicmm)andtheimagecoverage.TwotrainedreadersindependentlyanalyzedMRIimagesandwereblindedtodatesandorderoftheexams.Plaquepresencebyvesselsegmentwasrecordedforbothvisits.Changefrombaselineforeachidentifiedplaquewascategorizedasprogression,regressionandnochangebasedonthelumen(stenosis)andvesselwallassessments.Reliabilitywasassessedbykappastatisticsandintraclasscorrelations(ICC).Results:Atotalof134and149plaqueswereidentifiedatbaselineandfollow-up,respectively.Newplaques(n=15)weredetectedin11participants.Among134plaquesidentifiedatbaseline,26progressed,2regressedand106hadnodetectiblechange.Readerreliability(kappaorICC,(95％CI))was0.71(0.62,0.81)forplaquepresence(segment-based,overall),0.81(0.70,0.92)forplaqueprogression,0.80(0.54,0.93)forMaximumwallthicknessand0.65(0.32,0.88)formeanwallthickness.Conclusion:VesselwallMRIprovidesreliableMRImeasurementsofintracranialvessels,andenablesstudyingthenaturalhistoryofICADingeneralpopulation.
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