Modeling of caffeine release from a cellulosic substrate coated with microfibrillated cellulose

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户:yuxk781224
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  The past two decades have been packed with the development of a new bio-nano-material called microfibrillated cellulose (MFC).Simply obtained by a strong fibrillation of the cellulosic fibers,MFC consists of aggregates of cellulose microfibrils,and has diameters ranging from 20-60 nm and length ≥1 μm [1].These dimensions give it a high surface energy,and with the high amount of hydroxyl groups at its surface,MFC has the ability to form a tight nanoporous network at dried state.The applications of MFC have attracted much interest,and three years ago,it has been applied for the first time as drug delivery system.MFC has been used as spray-dried powder,aerogels,or films [2].In parallel,our group proposed a new concept on use of the nanoporous MFC network formed after coating onto paper substrate as sustained release system of active molecules.Promising results were achieved using caffeine as a model molecule [3].
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