Calcium phosphate (CaP) precipitates were developed as a transfection method for DNA in the 1970s [1].This procedure is very attractive because of its biocompatibility,economic materials,ease of preparation and high gene loading efficiency.However,the rapid growth of calcium phosphate particles after preparation results in low transfection efficiency if they are not used immediately.This fact prevents the use of this method in vivo and prompted the development of stabilizers.The development of PEGylated chelator for calcium phosphate particles is a very promising strategy [2].Furthermore,active targeting via the incorporation of a targeting ligand to the nanoparticles is expected to provide the most effective therapy.