延迟性脾反应对缺血性卒中长期神经功能恢复影响的研究

来源 :2016年中国生命电子学术年会 | 被引量 : 0次 | 上传用户：asdfzxcvasdf

【摘要】

：

脾脏免疫反应严重影响卒中病人的脑损伤程度，卒中早期脾切除可通过抑制外周炎症细胞的浸润降低脑损伤，而卒中后延迟性脾切和急性脾切除是否促进长期神经功能的恢复还未见报道。本研究采用大脑中动脉阻塞(MCAO)大鼠模型，分别在再灌即刻和再灌后3 天进行脾脏切除手术，利用神经功能评分评估脾切除对MCAO 大鼠的长期神经保护作用，利用TTC 和MAP-2 免疫组化分析大鼠短期和长期脑梗死体积，利用流式检测脑组织

【作者】

：

冉媛媛黄烁张雯秀胡晓明刘宗建

【机构】

：

首都医科大学附属北京潞河医院,北京101149

【出处】

：

2016年中国生命电子学术年会

【发表日期】

：

2016年5期

【关键词】

：

脾切除大脑中动脉阻塞(MCAO)大鼠模型神经功能梗死体积免疫细胞

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延迟性脾反应对缺血性卒中长期神经功能恢复影响的研究

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