Epilepsy(Ep)is one commonly disease of central nervous system,thats pathogenesis is very complicated,and still not clearly.Now numerous evidences support the notion that chronic and repetitive seizure or status epilepticus will severe damage patients cognitive function,especially learning and memory.Therefore, its very important to further investigate and reveal the mechanism of Ep, and search effective drugs for anti-seizure.Oxymatrine(OXY) is an organic-alkaloid of Lightyellow Sophora Root (LSR) extraction,has effective action about central inhibition.