N-cadherin-ERα-Src Signal Models Mediate the Synergistic Potentiation of Activation of PI3K/Akt Sign

来源 :2011第二届国际神经科技大会 | 被引量 : 0次 | 上传用户：liongliong521

【摘要】

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【作者】

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Dianshuai Gao Zixiao Shi Meng Wang Yaping Liu Xiaozhou Wang

【机构】

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Xu Zhou Medical College China

【出处】

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2011第二届国际神经科技大会

【发表日期】

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2011年3期

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　　Accumulating evidence indicates that glial cell line-derived neurotrophic factor (GDNF) synergizes with 17 β-estradiol to protect dopaminergic neurons, however, the mechanisms have not yet been elucidated.Based on the fact that either 17β-estradiol or GDNF can activate the intracellular PI3K/Akt signal pathway, we hypothesize that the synergic protection of dopaminergic neurons exerted by E2 and GDNF is ascribed to enhancing the activation of the cellular PI3K/Akt signal pathway in a certain way.

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N-cadherin-ERα-Src Signal Models Mediate the Synergistic Potentiation of Activation of PI3K/Akt Sign

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